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Scientists Uncover Genes Linked To Hair Loss

Scientists Uncover Genes Linked To Hair Loss

Researchers uncover genes linked to hair loss, raising hopes for new and effective hair loss treatments.

A new genetic finding may have pinpointed the cause of alopecia areata, and could lead to effective new drugs to cure hair loss.

In one of the first ever studies to uncover the genes linked to alopecia areata, scientists have identified eight genes they say are directly associated with the skin disease that causes hair loss in over 5.3 million Americans.

The genes identified are already associated with a number of other autoimmune disorders including type 1 diabetes and rheumatoid arthritis. Now, researchers at Columbia University Medical Center in New York suggest these genes could be targets for new alopecia areata treatments.

scientist find roots of alopecia 550x370 Scientists Uncover Genes Linked To Hair Loss

Genes Linked To Alopecia Identified

Study author Angela M. Christiano, PhD, a professor of dermatology and genetics and development at Columbia, and her colleagues, noted one gene in particular known as ULBP3.

This gene is normally not present in hair follicles, but ULBP3 proteins were found in high concentrations in hair follicles affected by alopecia areata.

ULBP3 attracts immune cells called cytotoxic cells. If an infection is present in the body, cytotoxic cells can help fight the infection or destroy damaged cells, but if there is no infection or damage, these immune cells end up attacking healthy tissue.

The ULBP3 proteins attract cells marked by a killer cell receptor, known as NKG2D, which is also involved in other autoimmune disorders and could potentially serve as a biomarker for alopecia areata.

Two other genes were also expressed in hair follicles, while the remaining five genes were involved in immune system response.

The findings are based on the genome analysis of 1,054 people with alopecia areata and 3,278 people without the disorder and appear in the July 1 issue of Nature.

“Finding the initial genes underlying alopecia areata is a big step forward, but the nature of the genes is even more exciting,” Christiano says.

“There seems to be a shared mechanism among organs that express NKG2D danger signals as part of the initiating process. And since drugs are already in development that target these pathways — because they are being tested to treat rheumatoid arthritis, type 1 diabetes, and other diseases where the NKG2D receptor is involved — we may soon be able to test these drugs in clinical trials for alopecia areata. Finally, we have the possibility of developing drugs that specifically target the mechanism behind the disease.”

Alopecia areata was originally thought to be associated with psoriasis; however, psoriasis treatments failed to offer any benefit in treating alopecia areata. There is a 1.7% lifetime risk for alopecia areata, which can begin with a sudden whitening of hair and then losing patches of hair on the scalp.

The condition may ultimately lead to complete scalp hair loss or even total body hair loss. The condition’s severity varies by person and the hair does grow back in some patients. However, alopecia areata greatly affects quality of life that can be socially marginalizing, particularly for children. Current treatments range from topical foams to steroid injections.

Vicki Kalabokes, president and CEO of the National Alopecia Areata Foundation, which funded Christiano’s early pilot studies on the genetic basis of alopecia areata, said:

“This research is very exciting, as alopecia areata affects a huge number of people worldwide, and there are very few treatments for it — resulting in an enormous unmet medical need…

“Hair loss is life-altering – sufferers, especially children, experience social stigma. It affects their quality of life and can lead to long-term psychosocial impact.”

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