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Blood Vessels Grown From Patients Skin

Blood Vessels Grown From Patients Skin

Cytograft Tissue Engineering Have Developed Blood Vessels From A Piece Of A Patients Skin.

blood vessels grown from skin Blood Vessels Grown From Patients SkinFrom a piece of a patients skin, researchers have recently grown blood vessels in a laboratory and then successfully implanted them back into the body to help restore blood flow to the patients damaged arteries and veins.

Cytograft Tissue Engineering of Novato, California made the first blood cells to ever be created from a patient’s skin in a process that takes six to nine months. Because the vessels are derived from the patients own cells they eliminate the need for anti rejection drugs and as they are devoid of any synthetic ‘scaffolding’, they avoid complications from inflammatory reactions.

blood vessels grown from skin 1.thumbnail Blood Vessels Grown From Patients SkinDoctors in Argentina performed the first human test of the vessels on six patients, the longest follow up among these subjects has been 13 months and two additional implants have been performed since the first report was submitted. Cytograft have also applied to the U.S. Food and Drug Administration for approval to begin testing in the U.S.

red blood cells vessel.thumbnail Blood Vessels Grown From Patients SkinTo grow the vessels, surgeons must perform a skin biopsy which takes about 15 mins. Under local anesthesia a strip of skin and a piece of vein about 2.5 cm long is removed from the back pf the patients hand or inner wrist. Technicians then use enzymes to extract fibroblast cells from the skin and endothelial cells from the inner lining of the vein. The cells are then grown by the millions as sheets in a laboratory. The fibroblasts provide a mechanical backbone for the sheets that are peeled and rolled into a tube.

The procedure holds promise for patients with damaged blood vessels as a result of diabetes, arteriosclerosis, birth defects and other problems. Dr. Toshiharu Shinoka, director of pediatric cardiovascular surgery at Yale plans to help conduct studies with Cytograft on the new procedure. When asked about the new developments he said,

“This techniques has a big potential in the vascular surgical field”

He also mentioned that the technique was a big advance over similar methods he used in operations on children in Japan.

The Cytograft team plans to publish a full report of their findings after 10 patients have been monitored for six more months. Dr. McAllister of Cytograft estimated the cost of the procedure to be around $15,000 to $25,000 but added that the price would be likely to fall with wider use.


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