SUMO proteins block cancer by repairing DNA damage...
Scientists have discovered a family of ‘limpet-like’ proteins that play a major role in repairing the DNA damage which can lead to cancer.
They hope the finding can provide a breakthrough in the hunt for a cancer prevention drug.
They hope the finding could pave the way for a new type of drug which could help kill cancer cells, and promote production of healthy replacements.
The proteins have an amazing ability to zero in on damaged areas, killing cancer cells and promoting the production of healthy replacements.
The breakthrough was uncovered independently by two teams, and appears in the journal Nature.
These troubleshooting proteins, known as Small Ubiquitin-like Modifiers (SUMO), track down the damaged DNA in the body. They then attach themselves to normal proteins, and guide them in to fix the genetic faults.
Using this method, the proteins are even able to repair double strand DNA breaks – the most severe type of DNA damage. When their work is done, the proteins detach themselves and move on.
One of the study teams was able to track this repair process on the BRCA1 gene associated with a high-risk of breast cancer. SUMO was shown to attach to the damaged gene, and switch it back on – helping prevent breast cancer forming.
Researcher Dr Jo Morris, from King’s College London, said:
“This new insight is the first step towards developing drugs which may protect normal cells from the side effects of chemotherapy, or improve the effectiveness of current breast cancer treatments.”
Dr Lesley Walker, of Cancer Research UK, which part-funded the study, said:
“DNA damage, particularly double strand DNA breaks, are a fundamental cause of cancer and we know that people who have mutations in the BRCA1 gene have a higher risk of developing some kinds of cancer…
“Discovering that these limpet-like proteins play such an important role in repair may provide new opportunities to stop cancer from growing…
“[But] This is an extremely complex and intricate biological process so it may be many years before we can use this knowledge to safely intervene and help treat cancer patients.”
TAGS :Breast, Cancer, Future, Genetics, Health, Health Care, Medical, Medicine, News, Scientific Study
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